Hormone Replacement Therapy (HRT)

Bioidentical hormone therapy pellets are custom-compounded estradiol or testosterone pressed into small, solid cylinders similar to a large grain of rice. Pellet production is highly regulated by the FDA.  

EvexiPEL Certified providers source pellets from FaramKeio, one of the leading 503B FDA-registered compounding pharmacies in the country. Each pellet is carefully compounded to the exact dose prescribed by your practitioner to meet your body’s unique needs and facilitate optimal absorption of your prescribed therapy. 

Patients who seek hormone therapy are often seeking relief from uncomfortable symptoms of hormone imbalance including hot flashes, night sweats, hair loss, insomnia, weight gain, brain fog, low energy, moodiness, irritability, anxiety, fatigue, and more. With pellet therapy, patients experience relief of these symptoms as well as additional benefits, such as improved libido, mental focus, and reduced risk of disease. 

The primary goal of hormone therapy is to address the root cause of these symptoms—hormone imbalance—and reach a state of hormone optimization. 

Bioidentical hormones are derived from natural sources, such as yams or soy, and designed to be structurally identical to the hormones produced by the human body. This feature ensures that when bioidentical hormones are supplemented to correct hormonal imbalance, the hormones react in the same manner as the hormones naturally produced by the body, therefore reducing side effects, supporting disease prevention, and alleviating uncomfortable symptoms. 

Compounded bioidentical hormones are not FDA-approved because each dose is tailored to the needs of each patient. The pharmacies and ingredients used to develop compounded bioidentical hormones are FDA-registered and approved.  

Some bioidentical hormones, such as Prometrium®, a bioidentical progesterone, and estriol, a bioidentical estrogen, are FDA-approved. 

There is no correlation to increased risk of breast or other cancer with the use of bioidentical hormones, as documented by countless peer-reviewed studies, analyses, and research. 

Some patients may experience temporary, undesirable side effects as their body adapts to the treatment. The most common side effects are increased hair growth and skin breakouts due to increased oil production. If you observe any side effects, tell your EvexiPEL certified provider so that he or she may adjust your treatment plan as needed. 

Bioidentical hormones are derived from natural sources, such as yams or soy, and designed to be structurally identical to the hormones produced by the human body. This feature ensures that when bioidentical hormones are supplemented to correct hormonal imbalance, the hormones react in the same manner as the hormones naturally produced by the body, therefore reducing side effects, supporting disease prevention, and alleviating uncomfortable symptoms. 

Compounded bioidentical hormones are not FDA-approved because each dose is tailored to the needs of each patient. The pharmacies and ingredients used to develop compounded bioidentical hormones are FDA-registered and approved.  

Some bioidentical hormones, such as Prometrium®, a bioidentical progesterone, and estriol, a bioidentical estrogen, are FDA-approved. 

There is no correlation to increased risk of breast or other cancer with the use of bioidentical hormones, as documented by countless peer-reviewed studies, analyses, and research. 

Bioidentical hormone pellet therapy is not shown to carry the same risks of certain cancers commonly affiliated with synthetic hormones, such as oral estrogen, chemical progestin, or hormone metabolites. These forms of synthetic hormones were cited in the well-known Women’s Health Initiative (WHI) and accurately linked to certain forms of cancer.  

Current research and data on bioidentical forms of estrogen and testosterone show a decreased risk of certain diseases. 

Hormone therapy begins with a complete lab evaluation to assess your health and hormone status. Using this information, your practitioner will develop a treatment plan. Your labs and symptoms will continue to be assessed prior to future insertions over the first several months of your treatment plan to evaluate outcomes and achieve optimization. 

During your treatment plan, men will need to maintain recommended routine PSA screenings with their primary care physician and women will need to continue with recommended routine screenings with their primary care physician, including mammograms and gynecological exams. 

Each treatment plan is individualized; therefore, the duration of each plan may vary. For patients seeking to maintain the benefits of hormone optimization, bioidentical hormone replacement therapy is the recommended treatment to help you feel your best every day. Discontinuing treatment may result in loss of hormone optimization and the return of uncomfortable symptoms of hormone imbalance. 

The plant-based hormones used in bioidentical hormone replacement therapy (BHRT) have not been tied to an increased risk of cancer or blood clots, as is the case with some synthetic hormones.

Common side effects of standard hormone pellet insertions include minor bleeding or bruising at the insertion site, extrusion of the pellet, discoloration of the skin and infection. However, Dr. Terri DeNeui designed EvexiPEL pellets and the EvexiPEL Method to optimize the insertion process and heavily decrease the risk of those side effects that can sometimes occur at the pellet insertion site.

The most common side effects associated with BHRT pellets after the first insertion process include increased hair growth, acne, oily skin, fatigue and increased body fat as the body gets used to the therapy.