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Hormone Replacement Therapy in Edina & Bloomington

Hormone Replacement Therapy (HRT) is a safe and effective treatment designed to restore hormonal balance and alleviate symptoms caused by age-related hormonal decline in both men and women. For women, HRT typically involves a customized blend of estrogen, progesterone, and sometimes testosterone to ease symptoms such as hot flashes, mood swings, night sweats, and decreased libido. In men, testosterone therapy is commonly used to combat fatigue, support muscle strength, and enhance sexual wellness. By replenishing essential hormones, HRT helps improve energy levels, mental clarity, emotional stability, and overall quality of life—empowering patients to feel more like themselves again.

To find out if you are a candidate:

Text:  Pellets to 651-946-8227

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What Is HRT?

Hormone Replacement Therapy (HRT) using bioidentical hormones offers a more natural and effective way to restore hormonal balance. Unlike traditional synthetic or animal-derived hormones, bioidentical hormones are chemically identical to those your body produces. This allows for better absorption, fewer side effects, and smoother results. Treatment options include creams, patches, pills, and long-lasting pellets—our preferred method for its steady, reliable hormone delivery over several months. As hormone levels normalize, many patients experience clearer skin, better sleep, increased energy, enhanced mood, and healthier hair and nails—boosting overall wellness and vitality.

Why Choose Skin Rejuvenation Clinic for HRT?

At Skin Rejuvenation Clinic, our approach to HRT is personalized and science-backed. We begin with comprehensive bloodwork to understand your unique hormone profile. From there, Isaac Waalen, PA-C, develops a customized treatment plan tailored to your specific symptoms and goals. When appropriate, we recommend pellet therapy for its consistent, long-term benefits and minimal maintenance. Located in the Edina and Minneapolis area, our welcoming clinic provides a comfortable space for you to heal and thrive. As a bonus, our VIP Luxe Membership offers exclusive savings on additional treatments—supporting your journey to graceful, healthy aging.

How it Works

Step 1: Assessment

At Skin Rejuvenation Clinic, we begin your Hormone Replacement Therapy (HRT) journey with a detailed and personalized assessment. This includes a full review of your medical and family history, a deep dive into your symptoms, and a discussion of lifestyle factors that may impact your hormone health. Comprehensive diagnostic testing—starting with initial blood work and followed by a five-week recheck—allows our team to evaluate your current hormone levels and overall wellness markers. This thorough process helps us uncover the root causes of your symptoms and ensures that your HRT plan is precisely tailored to your body’s needs, goals, and long-term health.

Step 2: Treatment Planning

At Skin Rejuvenation Clinic, Hormone Replacement Therapy (HRT) is never one-size-fits-all. Every treatment plan begins with a comprehensive medical evaluation to assess your symptoms, health history, and potential risk factors. Blood testing provides critical insight into your current hormone levels and helps determine which hormones—such as estrogen, progesterone, or testosterone—may offer the greatest benefit. Based on these findings, we create a tailored treatment plan with precise hormone dosages and clear timelines. Ongoing follow-up visits ensure your therapy remains safe, effective, and aligned with your evolving needs—allowing for adjustments that support long-term wellness and symptom relief.

Step 3: Treatment

Pellet therapy is an advanced form of bioidentical hormone replacement that delivers steady, long-lasting relief from hormone imbalance. Small, custom-compounded pellets, each about the size of a grain of rice, are inserted just beneath the skin during a quick, in-office procedure. These pellets release a consistent stream of hormones into the bloodstream, closely mimicking the body’s natural rhythms. Pellet therapy is ideal for both women experiencing symptoms of menopause and men with low testosterone, helping to restore energy, mood, libido, and overall well-being. Each pellet offers sustained benefits for several months, with simple, periodic replacements required to maintain results.

Step 4: Follow up

Ongoing follow-up care is a key component of successful Hormone Replacement Therapy (HRT). At Skin Rejuvenation Clinic, we monitor your progress through regular blood tests and symptom reviews to ensure your hormone levels stay balanced and effective. The first follow-up lab work is typically scheduled 4-6 weeks after your initial pellet insertion to evaluate your body’s response. During subsequent visits, we assess symptom relief, address any concerns, and plan for future treatments. Since pellets usually last between 3 to 6 months, a return of symptoms, such as fatigue, mood changes, or low libido, may signal it’s time for your next insertion. This proactive approach helps you maintain consistent results and optimal wellness year-round.

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Procedure At A Glance

Best Results

Improvements in sleep, mood, energy, and libido are often noticeable within 2 to 4 weeks of starting HRT.

Duration of Results

Pellets typically last 3-6 months. Women usually need replacements every 3-4 months, while men may need them every 4-6. Timing depends on factors like age, activity, and metabolism. Follow-up labs help determine your ideal schedule.

Hormone Replacement Therapy Treatment Recovery

Recovery is fast; most return to normal routines in a few days. Avoid strenuous activity for 3-5 days, and keep the area clean and dry. Minor swelling or bruising is normal. Contact us if you notice redness, discharge, or unusual swelling.

Risks & Complications

While HRT is generally safe, potential risks include bruising, infection, or pellet extrusion. Some may experience acne, mood changes, or weight shifts. All risks are reviewed during your consultation.

Procedure Time

The entire pellet insertion process takes under 30 minutes, with the actual procedure lasting just a few minutes.

Back to Work

Most patients return to work the same or the next day. Avoid vigorous activity for 3-4 days. Light walking or stairs is usually fine during recovery.

Treatment Details

Pre and Post Care Instructions

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Pre Care Instructions

1 Week Before Your Appointment:

  • Avoid anti-inflammatory medications such as ibuprofen, aspirin, naproxen, and supplements like fish oil, vitamin E, or turmeric, unless prescribed—these may increase bruising risk.
  • Complete all required lab work to ensure your hormone levels are properly evaluated.
  • Shower and shave the insertion area (upper buttock/hip) on the morning of your procedure.

Day of Your Appointment:

  • Wear loose, comfortable clothing.
  • Eat a light meal before your visit to avoid dizziness or lightheadedness.
  • Let your provider know if you:
    • Take blood thinners
    • Have diabetes, an autoimmune condition, or any current infection
    • Are allergic to lidocaine, adhesives, or topical antibiotics
two images, top image is a person meditating at the edge of a serene lake surrounded by forested mountains, symbolizing balance, wellness, and inner peace. The second image is a close-up of a woman’s toned midsection and hips in high-waisted nude shapewear, representing body contouring or skin rejuvenation.

Post Care Instructions

Immediately After the Procedure

  • Keep the area clean and dry for 24–48 hours. Leave bandages in place as instructed.
  • Avoid strenuous activity (exercise, lifting, or pressure on the site) for 3–4 days. Light walking is fine.
  • No baths, hot tubs, or swimming for at least 3–5 days to reduce infection risk.
  • Apply ice for 1–2 hours post-procedure to minimize swelling.

After 2-3 Days

  • Showering is typically okay after 24–48 hours, but avoid direct water pressure on the site.
  • Bandage care: Follow your provider’s instructions. Large dressings can be removed as directed; steri-strips should stay on for 5–7 days.
  • Skip moisturizers: Avoid applying lotions, creams, or gels near the site during early healing.

Frequently Asked Questions

What Are Hormone Replacement Therapy Pellets?

HRT pellets are tiny, rice-sized cylinders of bioidentical estradiol or testosterone, custom-compounded to match your unique hormone needs. They’re inserted just beneath the skin and deliver a steady dose of hormones over several months. At Skin Rejuvenation Clinic, we source our pellets from FDA-registered 503B pharmacies, including FarmaKeio, ensuring high safety and quality standards.

What Results Can I Expect from Bioidentical Hormone Therapy?

Patients often report relief from hot flashes, night sweats, insomnia, low libido, weight gain, brain fog, and fatigue. Additional benefits include improved mental clarity, mood, energy, and reduced risk of age-related disease. The goal is long-term hormone optimization—not just symptom relief.

Are Bioidentical Hormones Safer Than Synthetic Hormones?

Yes. Bioidentical hormones are plant-derived (from yams or soy) and molecularly identical to those your body naturally produces. This makes them easier for the body to absorb, often with fewer side effects. While compounded bioidentical hormones aren’t FDA-approved due to their individualized nature, the pharmacies and ingredients used are FDA-registered and regulated.

Do Bioidentical Hormones Increase the Risk of Cancer?

Unlike synthetic hormones (such as oral estrogen or chemical progestins), bioidentical hormone therapy—especially pellets—has not been linked to an increased cancer risk. In fact, current studies show they may help reduce the risk of certain diseases.

Are There Side Effects of HRT?

Some patients experience temporary side effects, especially during initial treatment. These may include:

  • Mild swelling, bruising, or tenderness at the insertion site
  • Acne or oily skin
  • Hair growth or changes in body composition
  • Fatigue (as the body adjusts)

Always report side effects to your provider so your treatment plan can be adjusted as needed.

How Are Hormone Levels Monitored?

HRT begins with comprehensive lab testing. Your provider uses these results to develop a customized plan. Follow-up labs are done within 4–6 weeks and before future insertions to monitor progress and adjust dosing.

Men should maintain PSA screenings with their primary care provider.

Women should continue routine mammograms and gynecological exams.

How Long Will I Need Hormone Pellet Therapy?

Treatment duration varies by individual, but many patients choose to stay on HRT long term to maintain hormone balance and symptom relief. Stopping therapy may lead to the return of symptoms.

What Are the Risks of Hormone Pellet Therapy?

Pellet therapy is generally low-risk, especially when performed using the EvexiPEL Method. Possible risks include:

  • Minor bleeding or bruising
  • Pellet extrusion
  • Localized infection
  • Temporary changes in skin or hair

All risks are discussed thoroughly during your consultation to ensure you’re a good candidate.

What Our Patients Are Saying

Reviews & Testimonials

LOVE this clinic and all staff. You have set the bar high in the Twin Cities market when...

- Home Lindsey P.

I've been seeing the practitioners at Skin Rejuvenation Clinic for over a year now and have been extremely...

- Home Alice M.

I can't wait until the next time!

- Generic Michelle T

Everyone that works at Skin Rejuvenation Clinic is top notch. They are always interested in me, my needs...

- AGE & SUN SPOTS Kathryn F.

It is always a wonderful experience to come here. The staff is welcoming, the medical professionals are knowledgeable...

- Rosacea, Redness, or Flushing

Knowledgeable, informative, helpful and professional. Care about your wants and needs and adjust to what works best for...

- Spider Veins Face, Body, and Under Eyes Kian D.

LOVE this clinic and all staff. You have set the bar high in the Twin Cities market when...

- Home Lindsey P.

I've been seeing the practitioners at Skin Rejuvenation Clinic for over a year now and have been extremely...

- Home Alice M.

I can't wait until the next time!

- Generic Michelle T

Everyone that works at Skin Rejuvenation Clinic is top notch. They are always interested in me, my needs...

- AGE & SUN SPOTS Kathryn F.

It is always a wonderful experience to come here. The staff is welcoming, the medical professionals are knowledgeable...

- Rosacea, Redness, or Flushing

Knowledgeable, informative, helpful and professional. Care about your wants and needs and adjust to what works best for...

- Spider Veins Face, Body, and Under Eyes Kian D.

LOVE this clinic and all staff. You have set the bar high in the Twin Cities market when...

- Home Lindsey P.

I've been seeing the practitioners at Skin Rejuvenation Clinic for over a year now and have been extremely...

- Home Alice M.

I can't wait until the next time!

- Generic Michelle T

Everyone that works at Skin Rejuvenation Clinic is top notch. They are always interested in me, my needs...

- AGE & SUN SPOTS Kathryn F.

It is always a wonderful experience to come here. The staff is welcoming, the medical professionals are knowledgeable...

- Rosacea, Redness, or Flushing

Knowledgeable, informative, helpful and professional. Care about your wants and needs and adjust to what works best for...

- Spider Veins Face, Body, and Under Eyes Kian D.

woman sitting on a staircase looking at the camera

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